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Objective To provide objective parameters for differentiating pancreatic cystic tumors via using computed tomography texture analysis (CTTA) to quantify the special imaging features of pancreatic cystadenomas.Methods Enhanced CT images of pancreas from patients who were admitted in Department of Radiology in First Hospital affiliated with Zhejiang University and First People's Hospital of Hangzhou City and pathologically diagnosed as pancreatic serous cystadenomas (n =48) and mucinous cystadenomas (n =34) from January 2009 to December 2016 were retrospectively analyzed.Regions of interest were drawn on the parenchymal phase CT images in 5 slices according to the border of the tumors.Mean grey level intensity (M),variance (V),entropy (E),skewness (Ske) and kurtosis (Kur) were obtained from fine texture (σ =1.0) to coarse texture (σ =2.5).Receiver operating characteristic (ROC) curve for texture parameters with statistically difference was drawn,and the area under curve (AUC),diagnostic sensitivity and specificity were calculated.The diagnostic accuracy of senior and junior doctors was compared with the traditional CT analysis method.Results Reliability coefficient of the two radiologists was 0.809 ～ 0.997 with high consistency.Compared with mucinous cystic tumors,serous cystadenomas had a significantly different V (5.93 ± 9.02 vs 1.29±0.62),E (2.39±0.61 vs2.02±0.39) and Kur(30.18 ±42.55 vs 8.80-±4.34) in Ske0 of 2.5 (P ＜0.05),and there were no statistically significant differences on other parameters.The AUC of differential parameters for diagnosing two kinds of cystic tumors ranged from 0.56 to 0.84.The diagnostic accuracy of the traditional CT analysis method by junior doctor and senior radiologist was 60％ and 71％,respectively.Conclusions CTTA can not only effectively quantify the heterogeneity of pancreatic cystadenomas,but also is effective in the differentiation.
RESUMO
Objective To explore the value of combined examination of CT and tumor marker in evaluation of prognosis of peripheral lung cancer.Methods 204 patients diagnosed as peripheral lung cancer were selected in this research and they were followed up for 3 years.CT plain and contrast-enhanced scan was applied to calculate the density of tumor edge enhancement.Serum levels of tumor markers including CEA,CA125,CY211 and CA 199 were examined in peripheral blood.The prognostic value of CT and/or tumor markers in evaluation of metastasis after 1,2 and 3 years was assessed.Results Serum level of CY211 was significantly correlated with metastasis rate after 1,2 and 3 years after diagnosis of peripheral lung cancer(r =0.763,P ＜0.05) ;metastasis rate increased significantly after 1,2 and 3 years along with increase of density of tumor edge enhancement.Combined examination of CT and CY211 increased detectable rate of metastasis of peripheral lung cancer.Conclusion Combined examination of CT and CY211 can increase detectable rate of metastasis,benefit evaluation of prognosis of peripheral lung cancer.
